Job Title: Postdoctoral Fellow
Job Ref: EBI_01119
Employer: Thornton Research Group
Job Location: EMBL-EBI Hinxton near Cambridge, UK
Closing Date: 15/02/2018
 
Job Description:

We are seeking to recruit a Postdoctoral Fellow for a position in the Thornton Research Group, working closely with the Gene Expression Team at EMBL-EBI and the Open Targets team, co-located on the Wellcome Genome Campus, near Cambridge, UK.

The aims of the project are twofold:

  • To develop meta-analysis methods for identifying gene expression signatures and linking these to disease phenotypes.
  • To investigate links between rare diseases and complex diseases with similar phenotypes, using expression data as an intermediate phenotype.

You will work closely with our pharma collaborators in Open Targets initially to identify gene signatures for Alzheimer's disease progression phenotypes, but the approach will also be extended to other diseases. Your methods will directly contribute to the data production pipelines of the Expression Atlas, which is one of EMBL-EBI’s core open resources. The atlas provides a powerful route to find information about gene and protein expression across species and biological conditions, such as different tissues, cell types, developmental stages and diseases among others. There are now expression data for more than 3,000 experiments (microarray and RNA-sequencing) from over 30 different organisms. Analyses on human disease data are directly fed into the Target Validation Platform of the Open Targets project and this project will contribute to this platform by providing expression disease signatures.


The Open Targets project is a collaborative effort involving teams in the Wellcome Trust Sanger Institute, the European Bioinformatics Institute, GlaxoSmithKline, Biogen and Takeda through a public-private initiative aiming at generating evidence on the validity of therapeutic targets, and is committed to sharing its data openly with the scientific community.

EMBL-EBI is part of the European Molecular Biology Laboratory (EMBL) and it is a world-leading bioinformatics centre providing biological data to the scientific community with expertise in data storage, analysis and representation. EMBL-EBI provides freely available data from life science experiments, performs basic research in computational biology and offers an extensive user training programme, supporting researchers in academic and industry. We have close ties with both the University of Cambridge and the Wellcome Trust Sanger Institute.

Qualifications and Experience

Essential:

  • PhD degree in Computational Biology, Bioinformatics, Computer Science or Mathematics
  • Bioinformatics data analysis methods development
  • Working in a unix-based environment and high performance computing cluster environment
  • Gene expression data analysis (NGS and microarrays)

Desirable:

  • Background in statistical methods development
  • Background in working with data from age-related neurodegenerative diseases

Strong technical, interpersonal and communication skills are key to this position. The scientists involved come from many different disciplines including biology, computational sciences and statisticians.

Benefits

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive stipend, a comprehensive pension scheme and health insurance, and family related benefits where applicable.

We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.

If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

Application Instructions

To apply please submit a covering letter and CV, with two referees, through our online system.

Additional Information

Applications are welcome from all nationalities - visa information will be discussed in more depth with applicants selected for interview.

EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone.

Applications will close at 23:00 GMT on the date listed above.

It is envisaged that interviews will take place on Tuesday, 13th March 2018.

 

Apply Now    https://www.embl.de/jobs/searchjobs/index.php?ref=EBI_01119&newlang=1&pos[]=0&loc[]=0